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Discovery and Biological Characterization of Capromorelin Analogues with Extended Half-Lives

✍ Scribed by Philip A. Carpino; et al. et al.


Publisher
John Wiley and Sons
Year
2003
Weight
143 KB
Volume
34
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

For Abstract see ChemInform Abstract in Full Text.


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✍ Marcos A. Fázio; Laurence Jouvensal; Françoise Vovelle; Philippe Bulet; M. Terês 📂 Article 📅 2007 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 508 KB

## Abstract Gomesin (__Gm__) is a potent antimicrobial peptide isolated from the spider Acanthoscurria gomesiana. The two disulfide bridges Cys^2,15^ and Cys^6,11^ facilitate the folding of the molecule in a β‐hairpin structure, conferring on the peptide a high stability in human plasma. We report