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Disassembly of polyethylenimine-DNA particles in vitro: Implications for polyethylenimine-mediated DNA delivery

✍ Scribed by Martin Bertschinger; Gaurav Backliwal; Arnaud Schertenleib; Martin Jordan; David L. Hacker; Florian M. Wurm


Book ID
113691344
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
783 KB
Volume
116
Category
Article
ISSN
0168-3659

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## Abstract ## Background Polyethylenimine (PEI) polyplexes mediate efficient gene transfer only at high +/βˆ’ charge ratios at which free noncomplexed PEI is present. The excess of PEI gives polyplexes a positive surface charge that plays a role in polyplex binding on the cell membrane. Although po