The lithium salts of 2-, 3-and 4-pyridinecarboxylic acids undergo deprotonation at the position adjacent to the carboxylate group when treated with LTMP in THF at 0 °C, -50 °C and -25 °C, respectively. The lithiation conditions could be extended to chloronieotinic acids, and even to an activated ben
✦ LIBER ✦
Directed ortho-lithiation of unprotected diphenylphosphinic acids
✍ Scribed by Víctor Yañez Rodríguez; Miguel Ángel del Águila; María José Iglesias; Fernando López Ortiz
- Book ID
- 116909613
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- French
- Weight
- 755 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0040-4020
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