ChemInform Abstract: Directed Lithiation of Unprotected Benzoic Acids.
✍ Scribed by B. BENNETAU; J. MORTIER; J. MOYROUD; J.-L. GUESNET
- Book ID
- 112023588
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 32 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0931-7597
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📜 SIMILAR VOLUMES
The lithium salts of 2-, 3-and 4-pyridinecarboxylic acids undergo deprotonation at the position adjacent to the carboxylate group when treated with LTMP in THF at 0 °C, -50 °C and -25 °C, respectively. The lithiation conditions could be extended to chloronieotinic acids, and even to an activated ben
The lithium salts of quinoline-2-carboxylic acid and 4-methoxyquinoline-2-carboxylic acid undergo deprotonation at C3 when treated with LTMP in THF at -25 and 0°C, respectively. The lithium salts of quinoline-3-and -4-carboxylic acids are more prone to nucleophilic addition; nevertheless, they are d