Directed aromatic functionalization in natural-product synthesis: Fredericamycin A, nothapodytine B, and topopyrones B and D
โ Scribed by Turner, Charles Dylan; Ciufolini, Marco A
- Book ID
- 120433101
- Publisher
- Beilstein Institut
- Year
- 2011
- Tongue
- English
- Weight
- 642 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1860-5397
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๐ SIMILAR VOLUMES
A general approach is reported for the synthesis of phenolic natural products having terpenoid side chains: (1) construction of the reouisite bromophenol ethers, (2) coupling the aromatic ring with a terpenoid chain through copper(I) ate complex, and (3) ether cleavage under neutral or basic conditi
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Exploitation of molecular symmetry can greatly improve the efficiency of syntheses. The symmetry embedded in the centrosymmetric AB dioxepane fragment of hemibrevetoxin B was exploited for the first time in the preparation of an established intermediate in its total synthesis. Desymmetrization of th