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Direct synthesis of α-substituted phosphonates

✍ Scribed by K Praveen Kumar; C Muthiah; Sudha Kumaraswamy; K.C Kumara Swamy

Book ID
104230470
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
85 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

The a-substituted phosphonates (OCH 2 CMe 2 CH 2 O)P(O)CH(X)(Ar) [X=Cl, OMe, NMe 2 and OSiMe 3 ], useful precursors for Horner-Wadsworth-Emmons reactions, are readily prepared by treating (OCH 2 CMe 2 CH 2 O)PX with an aromatic aldehyde. In the reaction of (OCH 2 CMe 2 CH 2 O)PCl with furfuraldehyde and cinnamaldehyde, the 5-chlorofurfurylphosphonate (OCH 2 CMe 2 CH 2 O)P(O)CH 2 (5-Cl-C 4 H 2 O) and the g-chlorophosphonate (OCH 2 CMe 2 CH 2 O)P(O)CH CH-CH(Cl)Ph, respectively, are formed in good yields.

📜 SIMILAR VOLUMES

Direct Synthesis of α-Substituted Phosph
Direct Synthesis of α-Substituted Phosphonates.
✍ K. Praveen Kumar; C. Muthiah; Sudha Kumaraswamy; K. C. Kumara Swamy 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB

## Abstract For Abstract see ChemInform Abstract in Full Text.