Direct radiofluorination of [18F]MH.MZ for 5-HT2A receptor molecular imaging with PET
✍ Scribed by Matthias M. Herth; Vasko Kramer; Nic Gillings; Frank Rösch; Gitte M. Knudsen
- Book ID
- 112132941
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- French
- Weight
- 448 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0022-2135
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In some psychiatric disorders 5-HT 2A receptors play an important role. In order to investigate those in vivo there is an increasing interest in obtaining a metabolically stable, subtype selective and high affinity radioligand for receptor binding studies using positron emission tomography (PET). Co
## Abstract 5‐HT~1A~ receptors are involved in a variety of psychiatric disorders and __in vivo__ molecular imaging of the 5‐HT~1A~ status represents an important approach to analyze and treat these disorders. We report herein the synthesis of three new fluoroethylated 5‐HT~1A~ ligands (AH1.MZ, AH2