Direct quantitation of antiseptic quaternary ammonium compounds by fast atom bombardment mass spectrometry

✍ Scribed by M.Bambagiotti Alberti; S. Pinzauti; G. Moneti; G. Agati; V. Giannellini; S.A. Coran; F.F. Vincieri

• Book ID: 103910615
• Publisher: Elsevier Science
• Year: 1984
• Tongue: English
• Weight: 429 KB
• Volume: 2
• Category: Article
• ISSN: 0731-7085
• DOI: 10.1016/0731-7085(84)80044-8

✦ Synopsis

The medicinally important quaternary ammonium salts benzyldimethyltetradecylammonium chloride (BDTA), cetylpyridinium chloride and benzethonium chloride, all afford, under fast atom bombardment (FAB) mass spectrometric conditions, abundant and persistent [M-Cl]+ species usefully amenable to quantitative analysis with the aid of thioglycerol as a liquid FAB matrix. The use of BDTA as an internal standard allowed a direct, precise and accurate determination of cetylpyridinium and benzethonium chlorides, either as pure samples or in dosage forms, in the concentration range 0.05-2 mg/ml.