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Direct plant gene delivery with a poly(amidoamine) dendrimer

โœ Scribed by Karthikeyan Pasupathy; Sijie Lin; Qian Hu; Hong Luo; Pu Chun Ke


Book ID
112011702
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
375 KB
Volume
3
Category
Article
ISSN
1860-6768

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## Abstract Dendritic poly(amidoamine)s (PAMAM)s were introduced into the side chains of disulfideโ€containing poly(amidoamine)s via repetitive Michael addition and amidation. The bioreducible poly(amidoamine)s grafted with dendritic polyamidoamines showed high buffer capacity, low cytotoxicity and

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## Abstract Three poly(amidoamine)s with pendant primary amines were synthesized by Michael polyaddition of a diamine to __N,Nโ€__methylenebis(acrylamide). The poly(amidoamine)s with primary and tertiary amines possess a high buffer capacity between pHโ€‰=โ€‰5 and 7, which facilitates the escape of poly