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Direct patterning of centrosome arrays as templates for the assembly of microtubules

✍ Scribed by Wen Shang; Jonathan S. Dordick; Robert E. Palazzo; Richard W. Siegel

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
237 KB
Volume
94
Category
Article
ISSN
0006-3592

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✦ Synopsis

We have achieved, for the first time, the selective patterning of centrosomes onto solid substrates. The use of such patterned centrosome arrays as templates for the directed polymerization of microtubules was also demonstrated. Centrosomes are small organelles in animal cells that serve as nucleation and organization centers of microtubules. Directed assembly of microtubules on the patterned centrosome arrays provides a new route to control the positions and directions of microtubules on surfaces. Combining the patterning of the isolated centrosomes and the directed growth of microtubules may lead to the generation of desired microtubule networks for bio-based nanodevices.

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## Abstract Branched oligonucleotides with symmetric arms **6**–**15**, which may contain biotin as a second recognition code, were prepared. These molecules are designed to be used for the directed assembly of nanomaterials. The branched structure of the desired oligonucleotides was confirmed by m