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Direct optical resolution of vesamicol and a series of benzovesamicol analogues by high-performance liquid chromatography

✍ Scribed by David L. Gildersleeve; Yong-Woon Jung; Donald M. Wieland

Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
549 KB
Volume
667
Category
Article
ISSN
1873-3778

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Direct optical resolution of a series of
Direct optical resolution of a series of pharmacologically active racemic sulfoxides by high-performance liquid affinity chromatography
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A series of pharmacologically active racemic sulfoxides was investigated with respect to optical resolution by an affinity chromatographic technique based on enantioselective interactions with immobilized bovine serum albumin. The results show that very small changes in the molecular structure of a