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Direct molecular analysis of a deletion of 3p in tumors from patients with sporadic renal cell carcinoma

✍ Scribed by Annemarie H. van der Hout; Klaas Kok; Anke van den Berg; J.Wolter Oosterhuis; Ben Carritt; Charles H.C.M. Buys

Book ID
119104012
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
235 KB
Volume
32
Category
Article
ISSN
0165-4608

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KA, B S , F M ), Sweden Deletions of the short arm of chromosome 3 and associated allele losses have been reported in the majority of sporadic renal cell carcinomas (RCC). O n the basis of the combined cytogenetic and molecular data, it is reasonable to assume that a putative RCC locus, which contri

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On a genetic level, renal-cell carcinoma has been characterized by an abnormality on the short arm of chromosome 3 (3p), which suggests the inactivation of a tumor suppressor gene. One tumor suppressor gene at 3p, the von Hippel-Lindau disease gene, is implicated in tumor development of a whole spec