Direct measurement of spin-lattice relaxation times of Phosphorus Metabolites in Human Myocardium

✍ Scribed by S. Neubauer; T. Krahe; R. Schindler; H. Hillenbrand; C. Entzeroth; M. Horn; W. R. Bauer; T. Stephan; K. Lackner; A. Haase; G. Ertl

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 452 KB
• Volume: 26
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910260209

✦ Synopsis

Abstract

T1 values of phosphorus metabolites visible in human cardiac ^31^P‐MR spectra were determined in 12 volunteers at 1.5 T. Consecutive spectra were acquired with varying pulse repetition time (TR) from 1.6 to 24 s; volume selection was achieved with ISIS. T 1's of creatine phosphate (CP), [γ‐P], [α‐P], and [β‐P] ATP, 2‐3 diphosphoglycerate, and phosphodiesters were 6.1 ± 0.5, 5.4 ± 4 0.5, 5.5 ± 0.5, 5.8 ± 1.0, 7.6 ± 1.0, and 5.0 ± 1.0 s, respectively. CP/ATP ratios showed little change with varying TR; linear regression of CP/ATP vs TR was of borderline significance (r = 0.28, P = 0.06). T1'S for CP and ATP were also determined in standard solution (20 m__M__ CP, 10 m__M__ ATP) yielding TI~cp~ of 8.7 ± 0.2 and T1~[γ‐P]‐atp~of 9.9 ± 0.7 s. Thus, T1'S for CP and ATP were similar at 1.5 T in both human heart and standard solution. In human cardiac ^31^P‐MR spectra, CP/ATP ratios may need little correction for partial saturation.