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Direct Interaction of SOS1 Ras Exchange Protein with the SH3 Domain of Phospholipase C-γ1 †

✍ Scribed by Kim, Myung Jong; Chang, Jong-Soo; Park, Seung Kook; Hwang, Jong-Ik; Ryu, Sung Ho; Suh, Pann-Ghill

Book ID: 126286632
Publisher: American Chemical Society
Year: 2000
Tongue: English
Weight: 153 KB
Volume: 39
Category: Article
ISSN: 0006-2960
DOI: 10.1021/bi992558t

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## Abstract Phospholipase C‐γ1 (PLCγ1) plays a critical role in cell growth and proliferation by generating the second messengers, diacylglycerol and 1, 4, 5‐inositol triphosphate. To investigate the roles of Src homology domain 2 and domain 3 of PLCγ1 in PLCγ1‐mediated cell signaling, we character