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Direct inhibition of the transforming growth factor-β pathway by protein-bound polysaccharide through inactivation of Smad2 signaling

✍ Scribed by Yoshihiro Ono; Tetsu Hayashida; Ayano Konagai; Hiroshi Okazaki; Kazuhiro Miyao; Shigeyuki Kawachi; Minoru Tanabe; Masahiro Shinoda; Hiromitsu Jinno; Hirotoshi Hasegawa; Masaki Kitajima; Yuko Kitagawa

Book ID
114703116
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
579 KB
Volume
103
Category
Article
ISSN
1347-9032

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## Abstract EBV‐encoded LMP‐1 is absolutely required for EBV transformation of cells. Previous studies showed that LMP‐1 is responsible for mediating resistance to the anti‐proliferative effects of TGF‐β that characterizes EBV‐transformed cells. To clarify the mechanisms of resistance to TGF‐β by L