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Direct ethoxycarbonyldifluoromethylation of aromatic compounds using Fenton reagent

✍ Scribed by Yuhki Ohtsuka; Tetsu Yamakawa

Book ID
108283512
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
1019 KB
Volume
67
Category
Article
ISSN
0040-4020

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An efficient synthesis of licofelone, an anti-inflammatory drug currently undergoing phase-III clinical studies, based on Fenton-type radical alkylation of 2,3-dihydro-1H-pyrrolizine 3 with iodoacetonitrile or iodoacetates is reported. The iodoacetates can be replaced by NaI and by the corresponding