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A synthesis of licofelone using Fenton’s reagent

✍ Scribed by Stanislav Rádl; Josef Černý; Ondřej Klecán; Jan Stach; Lukáš Plaček; Zuzana Mandelová

Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
163 KB
Volume
49
Category
Article
ISSN
0040-4039

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✦ Synopsis

An efficient synthesis of licofelone, an anti-inflammatory drug currently undergoing phase-III clinical studies, based on Fenton-type radical alkylation of 2,3-dihydro-1H-pyrrolizine 3 with iodoacetonitrile or iodoacetates is reported. The iodoacetates can be replaced by NaI and by the corresponding bromoacetate.

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✍ Jesús Beltrán de Heredia; Joaquín R Domínguez; Raquel López 📂 Article 📅 2004 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 232 KB

## Abstract This work evaluates Fenton oxidation for the removal of organic matter (COD) from cork‐processing wastewater. The experimental variables studied were the dosages of iron salts and hydrogen peroxide. The COD removal ranged from 17% to 79%, depending on the reagent dose, and the stoichiom