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Direct effects of carbachol on membrane potential and ion activities in leech glial cells

✍ Scribed by K. Ballanyi; W.-R. Schlue

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
260 KB
Volume
1
Category
Article
ISSN
0894-1491

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✦ Synopsis

Ion-selective double-barreled microelectrodes were used to measure the activities of intracellular K+ and Na+ (a&, aha) and the membrane potential (Em) in neuropile glial cells as well as extracellular Kt (ag) in the neuropile of segmental ganglia in the leech, Hirudo medicinalis. Bath-application of carbachol resulted in a prominent membrane depolarization. This depolarization was accompanied by transient increases of aka and a s , whereas a h decreased. It is suggested that the carbachol-induced depolarization and the underlying ion activity changes are due to activation of an acetylcholine receptor-coupled cation channel in the membrane of the neuropile glial cells.

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