Aerosolized recombinant human DNase (dornase alfa) reduces mucus viscoelasticity in vitro and improves pulmonary function in patients with cystic fibrosis (CF). We postulated that if dornase alfa could be delivered more peripherally to small airways in the lung in the form of smaller aerosol droplet
β¦ LIBER β¦
Direct dispensing of dornase alfa improves adherence and lung function in cystic fibrosis (CF)
β Scribed by M. Hagelberg; M.J. Dooley; S.G. Poole; D. Leung; M. Bailey; F. Finlayson; D. Clark; M. Braithwaite; T. Kotsimbos; J.W. Wilson
- Book ID
- 118641541
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 54 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1569-1993
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Airway inflammation and infection are present in patients with mild lung disease in cystic fibrosis (CF), suggesting the need for early treatment. In a previously reported large multicenter trial, dornase alfa improved pulmonary function and decreased the need for hospitalization in patients with CF