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Direct dispensing of dornase alfa improves adherence and lung function in cystic fibrosis (CF)

✍ Scribed by M. Hagelberg; M.J. Dooley; S.G. Poole; D. Leung; M. Bailey; F. Finlayson; D. Clark; M. Braithwaite; T. Kotsimbos; J.W. Wilson


Book ID
118641541
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
54 KB
Volume
7
Category
Article
ISSN
1569-1993

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πŸ“œ SIMILAR VOLUMES


Effect of smaller droplet size of dornas
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Aerosolized recombinant human DNase (dornase alfa) reduces mucus viscoelasticity in vitro and improves pulmonary function in patients with cystic fibrosis (CF). We postulated that if dornase alfa could be delivered more peripherally to small airways in the lung in the form of smaller aerosol droplet

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Airway inflammation and infection are present in patients with mild lung disease in cystic fibrosis (CF), suggesting the need for early treatment. In a previously reported large multicenter trial, dornase alfa improved pulmonary function and decreased the need for hospitalization in patients with CF