Editorial for effect of dornase alfa on inflammation and lung function: Potential role in the early treatment of cystic fibrosis
β Scribed by Harm A.W.M. Tiddens
- Book ID
- 116619758
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 71 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1569-1993
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π SIMILAR VOLUMES
Aerosolized recombinant human DNase (dornase alfa) reduces mucus viscoelasticity in vitro and improves pulmonary function in patients with cystic fibrosis (CF). We postulated that if dornase alfa could be delivered more peripherally to small airways in the lung in the form of smaller aerosol droplet
Airway inflammation and infection are present in patients with mild lung disease in cystic fibrosis (CF), suggesting the need for early treatment. In a previously reported large multicenter trial, dornase alfa improved pulmonary function and decreased the need for hospitalization in patients with CF