Direct detection of peptides and proteins on a microfluidic platform with MALDI mass spectrometry
β Scribed by Yang, Mian; Chao, Tzu-Chiao; Nelson, Randall; Ros, Alexandra
- Book ID
- 111967698
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 404 KB
- Volume
- 404
- Category
- Article
- ISSN
- 1618-2650
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## Abstract | ββI. | Introduction | 282 | | | A.ββ4βHydroxyβ__trans__β2βNonenal (HNE): Biological Effects and Mechanism of Formation | 282 | | | B.ββHNE Reactivity and Reaction Mechanisms with Target Proteins | 282 | | | C.ββHNE: Pathological Implications | 284 | | βII. | Analytical Approaches f
Capillary zone electrophoresis (CZE) coupled with an on-line mass spectrometric (MS) detection system by an atmospheric pressure electrospray ionization (ESI) interface has been used successfully for separations of peptide and protein mixtures. For CZE-MS, ESI produces multiply charged molecular ion