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Direct current iontophoretic transdermal delivery of peptide and protein drugs

✍ Scribed by Yie W. Chien; O. Siddiqui; W.-M. Shi; P. Lelawongs; J.-C. Liu

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
943 KB
Volume
78
Category
Article
ISSN
0022-3549

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Iontophoretic transdermal delivery of sumatriptan: Effect of current density and ionic strength
✍ A. FemenΓ­a-Font; C. Balaguer-FernΓ‘ndez; V. Merino; A. LΓ³pez-Castellano πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 69 KB

Iontophoretic transdermal delivery of sumatriptan was investigated in vitro. Among the conditions tested, 0.25 mA/cm 2 and low ionic strength (NaCl 25 mM) was the best experimental condition to increase its transport across the skin. The flux increased 385-fold respective to passive diffusion, thus