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Iontophoretic transdermal delivery of sumatriptan: Effect of current density and ionic strength

✍ Scribed by A. Femenía-Font; C. Balaguer-Fernández; V. Merino; A. López-Castellano

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 69 KB
Volume: 94
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.20447

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✦ Synopsis

Iontophoretic transdermal delivery of sumatriptan was investigated in vitro. Among the conditions tested, 0.25 mA/cm 2 and low ionic strength (NaCl 25 mM) was the best experimental condition to increase its transport across the skin. The flux increased 385-fold respective to passive diffusion, thus resulting in a transdermal flux of sumatriptan of 1273 AE 83 nmol/cm 2 h.

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