Direct conversion of nitriles to .alpha.-alkylated aldehydes
โ Scribed by Goering, Harlan L.; Tseng, Chung Chyi
- Book ID
- 125533824
- Publisher
- American Chemical Society
- Year
- 1981
- Tongue
- English
- Weight
- 443 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0022-3263
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๐ SIMILAR VOLUMES
Ab~mrt: O-Arylcarbamoylated hydroxylamine tosylate reacts with aldehydes at room temperature to give the corresponding O-earbamoylated oximes. The reaction of earbamoylated hydroxylamine with aromatic aldehydes in THF or in toluene at reflux affords the corresponding nitriles and anilinium tosylate
The synthesis of nitriles is a process which, in the past, has frequently required quite n vigorous reaction conditions'. In recent years, however, interest has arisen in examining milder methods for nitrile synthesis 3-5 . As a contribution to the solution of this problem of reaction conditions, w
Treatment of an ester with dimethylaluminum amide (3 in refluxing xylene produces a nitrile in good yield.