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Direct Cloning of DNA Sequences from the Common Fragile Site Region at Chromosome Band 3p14.2

โœ Scribed by Feyruz V. Rassool; Michelle M. Le Beau; Mei-Ling Shen; Mary E. Neilly; Rafael Espinosa III; S.Tiong Ong; Ferenc Boldog; Harry Drabkin; Robert McCarroll; Timothy W. McKeithan


Book ID
115613284
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
409 KB
Volume
35
Category
Article
ISSN
0888-7543

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Precise localization of the FHIT gene to
โœ S. Tiong Ong; Kwun M. Fong; Scott A. Bader; John D. Minna; Michelle M. Le Beau; ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 154 KB ๐Ÿ‘ 2 views

Chromosomal or allelic losses at 3p14 are common in a variety of human tumors, including those of the lung, breast, kidney, and head and neck. This suggests the existence of a tumor suppressor gene in this band. A promising candidate is the recently cloned FHIT gene, which spans the common fragile s