Translocation t(3;8)(p14.2;q24.1) in renal cell carcinoma affects expression of the common fragile site at 3p14(FRA3B) in lymphocytes
β Scribed by Thomas W. Glover; Jane F. Coyle-Morris; Frederick P. Li; Robert S. Brown; Carol S. Berger; Robert M. Gemmill; Frederick Hecht
- Book ID
- 119103748
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 304 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0165-4608
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Chromosomal or allelic losses at 3p14 are common in a variety of human tumors, including those of the lung, breast, kidney, and head and neck. This suggests the existence of a tumor suppressor gene in this band. A promising candidate is the recently cloned FHIT gene, which spans the common fragile s
## Abstract Studying the molecular basis of familial renal cell carcinoma (RCC) has allowed identification of novel RCC genes involved in the pathogenesis of both inherited and sporadic RCC. We describe a constitutional balanced t(3;8)(p14;q24.1) translocation found in a brother and sister with bil