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Direct Catalytic Anti-Markovnikov Addition of Carboxylic Acids to Alkenes

โœ Scribed by Perkowski, Andrew J.; Nicewicz, David A.


Book ID
120557456
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
450 KB
Volume
135
Category
Article
ISSN
0002-7863

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Ruthenium-catalyzed selective anti-Marko
โœ Karen Melis; Pawel Samulkiewicz; Jacek Rynkowski; Francis Verpoort ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 142 KB

Carboxylic acids react with terminal alkynes in the presence of a catalytic amount of RuCl x (p-cymene)(triazol-5-ylidene) to selective generate Z-alk-1-en-1-yl esters. The anti-Markovnikov and trans addition on the terminal alkyne gives access to Z-alkene derivatives of phenylacetylene, t-butylacet