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Direct carrier detection and prenatal diagnosis of Sicilian and Spanish (δβ)°-thalassemias

✍ Scribed by Nada Ghanem; Michael Vidaud; François Plassa; Josiane Martin; Michel Goossens


Book ID
115637957
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
75 KB
Volume
7
Category
Article
ISSN
0890-8508

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Carrier detection and prenatal diagnosis
✍ Tsang-Ming Ko; Li-Hui Tseng; Fon-Jon Hsieh; Pi-Mei Hsu; Tzu-Yao Lee 📂 Article 📅 1992 🏛 Springer 🌐 English ⚖ 523 KB

Alpha-thalassemia of Southeast Asian deletion (--SEA/) is very common in Southeast Asia. Homozygosity of this genotype is the major cause of Hb Bart's hydrops fetalis in Taiwan. With polymerase chain reaction using three oligonucleotide primers bridging the common deletion breakpoint, a DNA fragment