Direct and Selective Functionalization of a Tetrahydro-β-carboline at Position 4
✍ Scribed by Rannoux, Claire; Roussi, Fanny; Retailleau, Pascal; Guéritte, Françoise
- Book ID
- 118741566
- Publisher
- American Chemical Society
- Year
- 2010
- Tongue
- English
- Weight
- 394 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1523-7060
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📜 SIMILAR VOLUMES
The copper-promoted reaction of B-lactams with t-butyl perbenzoate results in benzoyloxylation of the azetidin-2-one ring at the C-4 position. There is no competing reaction at the C-3 position, but reaction at exocyclic carbon a to nitrogen competes with ring substitution.
Considerable effort has been expended in the synthesis of deoxylluoro sugarslm6 as a result of interest in such analogs for use as hexokinase inhibitors7, as carriers of l\*F in positron emission tomography8 (PET), and as possible anticancer agents9. Also, fluorinated pentofuranose nucleosides have