Direct and Indirect Enzymatic Methods for the Preparation of Enantiopure Cyclic β-Amino Acids and Derivatives from β-Lactams
✍ Scribed by E. Forro; F. Fueloep
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 56 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
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Several derivatives of homopipecolic acid are prepared by αthiazolidineacetic acids by epimerisation experiments. A method for resolution of the obtained racemic β-amino acids amino alkylation of malonic acid with cyclic imines 6 and 7. These are prepared on a large scale and with different by diast
## Abstract The first direct enzymatic method is reported for the synthesis of __cis__ and __trans__ β‐amino acid enantiomers through the lipase‐catalyzed enantioselective hydrolysis of alicyclic β‐amino esters in organic media. High enantioselectivities (__E__ usually >100) were observed when the