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Diphtheria Toxin Binds to the Epidermal Growth Factor (EGF)-like Domain of Human Heparin-binding EGF-like Growth Factor/Diphtheria Toxin Receptor and Inhibits Specifically Its Mitogenic Activity

โœ Scribed by Mitamura, T.; Higashiyama, S.; Taniguchi, N.; Klagsbrun, M.; Mekada, E.


Book ID
126014673
Publisher
The American Society for Biochemistry and Molecular Biology
Year
1995
Tongue
English
Weight
858 KB
Volume
270
Category
Article
ISSN
0021-9258

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## Abstract Heparinโ€binding EGFโ€like growth factor (HBโ€EGF), which belongs to the EGFโ€family of growth factors, was isolated from the conditioned medium of macrophageโ€like cells. To investigate the effect of __N__โ€ and __C__โ€terminal residues of the EGFโ€like domain of HBโ€EGF in the binding affinity