The cell-penetrating peptide domain from human heparin-binding epidermal growth factor-like growth factor (HB-EGF) has anti-inflammatory activity in vitro and in vivo

High glucose and hyperosmolarity increas

High glucose and hyperosmolarity increase heparin-binding epidermal growth factor-like growth factor (HB-EGF) production in cultured human aortic endothelial cells

✍ Hideki Asakawa; Jun-Ichiro Miyagawa; Shigeki Higashiyama; Katsutoshi Goishi; Tos 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 900 KB

## Abstract Heparin‐binding epidermal growth factor‐like growth factor (HB‐EGF) has been shown to be a potent smooth muscle cell (SMC) mitogen and chemoattractant, and might be a candidate factor for the progression of atherosclerosis. We have investigated the effects of high glucose and hyperosmol