β Scribed by Ingrid De Meester, Anne-Marie Lambeir, Paul Proost, Simon ScharpΓ© (auth.), Nathan Back, Irun R. Cohen, David Kritchevsky, Abel Lajtha, Rodolfo Paoletti (eds.)
No coin nor oath required. For personal study only.
Proceedings of the International Conference on Dipeptidyl Aminopeptidases, held September 26-28, 2002, in Berlin, Germany.
Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes.
Leading experts in this field have contributed to this book which presents a state-of-the-art view on these enzymes, at a time when our understanding of their function is growing ever more rapidly and therapeutic options become imminent. The sections of the book focus on various topics:
- Structure and function of dipeptidyl aminopeptidases,
- DPP IV-like proteins,
- Immune mechanisms and immune disorders,
- Cancer and angiogenesis,
- Diabetes and metabolism,
- Therapeutic implications.
Dipeptidyl Peptidase IV Substrates....Pages 3-17
Structure-Function Relationship of DPP IV: Insights into its Dimerisation and Gelatinase Activity....Pages 19-27
Exploration of the Active Site of Dipeptidyl Peptidase IV From Porphyromonas gingivalis ....Pages 29-35
Modification of the Biological Activity of Chemokines by Dipeptidyl Peptidase IV β a Side Effect in the Use of Inhibitors?....Pages 37-47
Molecular Chimeras and Mutational Analysis in the Prolyl Oligopeptidase Gene Family....Pages 49-55
The Specificity of DP IV for Natural Substrates is Peptide Structure Determined....Pages 57-63
New Results on the Conformations of Potent DP IV (CD26) Inhibitors bearing the N-terminal MWP Structural Motif....Pages 65-68
Different Inhibition Mechanisms of Dipeptidyl Peptidase IV by Tryptophan Containing Peptides and Amides....Pages 69-72
Re-Uptake Mechanisms of Peptide Fragments after DPP IV-Mediated Proteolysis in the Peripheral Nervous System....Pages 73-76
Dipeptidyl Peptidase IV Gene Family....Pages 79-86
Seprase-DPPIV Association and Prolyl Peptidase and Gelatinase Activities of the Protease Complex....Pages 87-94
Dipeptidyl Peptidase-IV Activity and/or Structure Homologues (DASH) in Transformed Neuroectodermal Cells....Pages 95-102
Characterisation of Human DP IV Produced by a Pichia pastoris Expression System....Pages 103-108
Isolation and Characterization of Attractin-2....Pages 109-113
Investigation of DP IV-dependent Protein-Protein Interactions using Surface Plasmon Resonance....Pages 115-119
Synergistic Action of DPIV and APN in the Regulation of T Cell Function....Pages 123-131
CD26/DPP IV in Experimental and Clinical Organ Transplantation....Pages 133-143
CD26 is Involved in the Regulation of T-Cell Plasma Membrane Compartmentation....Pages 145-153
Inhibition of Dipeptidylpeptidase IV (DPP IV, CD26) Activity Modulates Surface Expression of CTLA-4 in Stress-Induced Abortions....Pages 155-163
Dipeptidyl Peptidase IV/CD26 in T Cell Activation, Cytokine Secretion and Immunoglobulin Production....Pages 165-174
Dipeptidyl Peptidase IV Inhibitors with the N-terminal MXP Sequence: Structure-Activity-Relationships....Pages 175-179
On the Role of Dipeptidyl Peptidase IV in the Digestion of an Immunodominant Epitope in Celiac Disease....Pages 181-187
The Properties of Human and Bovine CD8+CD26+ T Cells Induced by a Microbial Superantigen....Pages 189-193
DPPIV and Seprase in Cancer Invasion and Angiogenesis....Pages 197-203
Glutamate Carboxypeptidase II Inhibition as a Novel Therapeutic Target....Pages 205-213
Dual Role of Dipeptidyl Peptidase IV (DPP IV) in Angiogenesis and Vascular Remodeling....Pages 215-222
CD26 Expression on Cutaneous Infiltrates from Patients with Cutaneous T-Cell Lymphoma (CTCL)....Pages 223-234
Intrahepatic Expression of Collagen and Fibroblast Activation Protein (FAP) in Hepatitis C Virus Infection....Pages 235-243
Expression of CD26/Dipeptidyl Peptidase IV in Endometrial Adenocarcinoma and its Negative Correlation with Tumor Grade....Pages 245-248
Adhesion Potency to Mesothelial Cells by Overexpression of Dipeptidyl Peptidase IV....Pages 249-252
Survival Time and Invasive Activity due to Dipeptidyl Peptidase IV Overexpression in Ovarian Carcinoma....Pages 253-256
Dipeptidylpeptidase IV Activities in Prostatic Secretions....Pages 257-260
Implementation of GLP-1 Based Therapy of Type 2 Diabetes Mellitus Using DPP-IV Inhibitors....Pages 263-279
Dipeptidyl Peptidase IV Inhibition in Animal Models of Diabetes....Pages 281-291
Glucose-dependent Insulinotropic Polypeptide (GIP): Development of DP IV-Resistant Analogues with Therapeutic Potential....Pages 293-301
Neutral Endopeptidase 24.11 and Dipeptidyl Peptidase IV are Both Involved in Regulating the Metabolic Stability of Glucagon-like Peptide-1 in vivo ....Pages 303-312
DPP IV, Immune Parameters, and Psychometrical Variables in Patients with Eating Disorders....Pages 313-320
DPP IV and Mental Depression in Crohnβs Disease....Pages 321-331
Microscopic Acid-Base Equilibra of Alanyl-boroAlanine....Pages 333-338
Acylated Hydroxamates as Selective and Highly Potent Inhibitors of Dipeptidyl Peptidase I....Pages 339-343
CD26-/DPP IV-Positive Lymphocytes in Murine Acute Experimental Colitis....Pages 345-350
Neuroprotective Effects of Inhibitors of Dipeptidyl Peptidase-IV In Vitro and In Vivo....Pages 351-355
Immunology; Pharmacy; Internal Medicine; Biochemistry, general
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