Dipeptidyl Aminopeptidases: Basic Science and Clinical Applications

✍ Scribed by Inger Brandt, Anne-Marie Lambeir, Marie-Berthe Maes, Simon Scharpé, Ingrid De Meester (auth.), Uwe Lendeckel, Dirk Reinhold, Ute Bank (eds.)

• Publisher: Springer US
• Year: 2006
• Tongue: English
• Leaves: 228
• Series: Advances in Experimental Medicine and Biology 575
• Edition: 1
• Category: Library

✦ Synopsis

Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses, and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in the field will contribute to this book, which will present a state-of-the-art view on these enzymes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent. The sections of the book will focus on various topics including DP IV and related enzymes in: expression and function, metabolic disorders, immune mechanisms and immune disorders, neuronal diseases and cancer, and related drug development.

✦ Table of Contents

Front Matter....Pages 1-1
Peptide Substrates of Dipeptidyl Peptidases....Pages 3-18
Phosphorus-Containing Inhibitors of Proteolytic Enzymes....Pages 19-26
Biochemical Properties of Recombinant Prolyl Dipeptidases DPP-IV and DPP8....Pages 27-32
Prediction of Dipeptidyl Peptidase (DP) 8 Structure by Homology Modelling....Pages 33-42
Front Matter....Pages 43-43
Structure and Function in Dipeptidyl Peptidase IV and Related Proteins....Pages 45-54
Expression and Function of Dipeptidyl Peptidase IV and Related Enzymes in Cancer....Pages 55-62
DP8 and DP9 have Extra-Enzymatic Roles in Cell Adhesion, Migration and Apoptosis....Pages 63-72
In Vivo Effects of a Potent, Selective Dppii Inhibitor....Pages 73-85
Expression of Dipeptidyl Peptidase IV-Like Enzymes in Human Peripheral Blood Mononuclear Cells....Pages 87-91
Dipeptidyl Peptidase 8 Has Post-Proline Dipeptidyl Aminopeptidase and Prolyl Endopeptidase Activities....Pages 93-102
Prolyl Endopeptidase Cleaves the Apoptosis Rescue Peptide Humanin and Exhibits an Unknown Post-Cysteine Cleavage Specificity....Pages 103-108
Distribution of Dipeptidyl Peptidase Iv-Like Activity Enzymes in Canine and Porcine Tissue Sections by RT-PCR....Pages 109-116
Front Matter....Pages 117-117
Relative Contribution of Incretins to the Glucose Lowering Effect of DP IV Inhibitors in Type 2 Diabetes Mellitus (T2DM)....Pages 119-133
Dipeptidyl Peptidase IV: A Molecular Switch of Vascular Actions of Neuropeptide Y....Pages 135-140
Front Matter....Pages 141-141
Dipeptidylpeptidase IV (DPIV) and Alanyl-Aminopeptidases (AAPs) as a New Target Complex for Treatment of Autoimmune and Inflammatory Diseases—Proof of Concept in a Mouse Model of Colitis....Pages 143-153
Dipeptidyl Peptidases and Inflammatory Bowel Disease....Pages 155-162
Possible Role of DP IV Inhibitors in Acne Therapy....Pages 163-167
Dipeptidyl Peptidase-IV Activity and/or Structure Homologs (DASH): Contributing Factors in the Pathogenesis of Rheumatic Diseases?....Pages 169-174
Front Matter....Pages 175-175
Dipeptidyl Peptidase IV (DP IV, CD26) and Aminopeptidase N (APN, CD13) as Regulators of T Cell Function and Targets of Immunotherapy in CNS Inflammation....Pages 177-186
CD26/DP IV in T Cell Activation and Autoimmunity....Pages 187-193
Front Matter....Pages 195-195
DPIV/CD26 and FAP in Cancer: A Tale of Contradictions....Pages 197-206
Type-II Transmembrane Prolyl Dipeptidases and Matrix Metalloproteinases in Membrane Vesicles of Active Endothelial Cells....Pages 207-212
Extra-Enzymatic Roles of DPIV and FAP in Cell Adhesion and Migration on Collagen and Fibronectin....Pages 213-222
Role of Neuropeptide Y and Dipeptidyl Peptidase IV in Regulation of Ewing’s Sarcoma Growth....Pages 223-229
The Role of CD26/DPP IV in Preservation of Early Pulmonary Graft Function....Pages 231-235

✦ Subjects

Immunology; Infectious Diseases; Neurosciences; Metabolic Diseases; Medical Biochemistry; Diabetes