Dipeptide-Catalyzed Asymmetric Aldol Condensation of Acetone with (N-Alkylated) Isatins
β Scribed by Luppi, Gianluigi; Cozzi, Pier Giorgio; Monari, Magda; Kaptein, Bernard; Broxterman, Quirinus B.; Tomasini, Claudia
- Book ID
- 111671034
- Publisher
- American Chemical Society
- Year
- 2005
- Tongue
- English
- Weight
- 225 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
Cinchona alkaloids were first successfully reported to promote enantioselective Phospho-Aldol reaction of diphenyl phosphite to a variety of N-alkylated isatin derivatives in good to excellent yields (up to 99%) and moderate to good enantioselectivities (up to 73% ee) almost in no time.
Novel primary-tertiary diamine organocatalysts derived from L-serine were utilized to promote enantioselective aldol reaction of acetone with a-ketoesters. The desired products were obtained in high yields and with good to excellent enantioselectivities (up to 95% ee).