Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors
✍ Scribed by Liaman K Mamedova; Bhalchandra V Joshi; Zhan-Guo Gao; Ivar von Kügelgen; Kenneth A Jacobson
- Book ID
- 113487090
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 177 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0006-2952
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
Benzofuran-substituted urea analogs have been identified as novel P2Y(1) receptor antagonists. Structure-activity relationship studies around the urea and the benzofuran moieties resulted in compounds having improved potency. Several analogs were shown to inhibit ADP-mediated platelet activation.