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Dihedral-angle dependence of the vicinal 15N,13C spin-coupling constants. A new NMR parameter for the conformational analysis of amino acids and peptides

✍ Scribed by Masatsune Kainosho; Takashi Tsuji

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
394 KB
Volume
17
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

The first successful observation of the vicinal ^15^N,^13^C spin‐coupling constants in a series of amino acids, comprising Val, Ile, Leu and Thr, in which the α‐nitrogens are fully replaced with ^15^N, is described. A Karplus‐type dihedral‐angle dependence was noted for the coupling constants between the α‐nitrogen and γ‐carbon nuclei which may, in turn, be applied to the conformational analysis of other amino acids and small peptides. The potential usefulness and limitation of this new parameter in such applications is briefly discussed.

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