Digoxin-interactions in man: Spironolact
โ
A. Hedman; B. Angelin; A. Arvidsson; R. Dahlqvist
๐
Article
๐
1992
๐
Springer
๐
English
โ 549 KB
The possibility of an inhibitory effect of spironolactone on the biliary clearance of digoxin has been investigated in 6 healthy subjects. Plasma clearance and the renal and biliary clearance of digoxin were determined twice at steady state (digoxin 0.5 to 1 mg.d-1 p.o. for 6 days), alone or in comb