Digoxin-interactions in man: Spironolactone reduces renal but not biliary digoxin clearance
✍ Scribed by A. Hedman; B. Angelin; A. Arvidsson; R. Dahlqvist
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 549 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0031-6970
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✦ Synopsis
The possibility of an inhibitory effect of spironolactone on the biliary clearance of digoxin has been investigated in 6 healthy subjects. Plasma clearance and the renal and biliary clearance of digoxin were determined twice at steady state (digoxin 0.5 to 1 mg.d-1 p.o. for 6 days), alone or in combination with spironolactone 200 mg daily, after an intravenous dose of digoxin (0.7 x oral dose) on Day 7. Plasma and urine were collected for 48 h. Biliary clearance of digoxin was determined on Day 8 by a duodenal perfusion technique. During spironolactone treatment plasma digoxin clearance tended to be lower (255 vs 224 ml/min; P = 0.057) and renal clearance significantly lower (166 vs 144 ml/min), while the biliary clearance of digoxin remained unchanged (106 vs 103 ml/min). Thus, spironolactone reduced the renal clearance of digoxin by an average of 13%, without affecting its biliary clearance.