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Difluoromethylation Reactions of Ethyl Pyruvate with the TDAE — A Mild Approach to the Synthesis of 3,3-Difluoro-2-hydroxy-2-methyl-4-oxo-butyric Ethyl Esters Derivatives.

✍ Scribed by Maurice Medebielle; Katsuya Kato; William R. Dolbier Jr.


Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
33
Category
Article
ISSN
0931-7597

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## Abstract The reaction of enamine (I) with ethyl hemiacetal (II) followed by acid hydrolysis and subsequent reduction of the intermediate aldehyde gives rise to the diastereomeric mixture of diols (III) and (IV).