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Difluorinated analogues of shikimic acid

✍ Scribed by Lovely Begum; Julian M Box; Michael G.B Drew; Laurence M Harwood; Jane L Humphreys; David J Lowes; Gareth A Morris; Perrine M Redon; Francine M Walker; Roger C Whitehead

Book ID: 104205380
Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 405 KB
Volume: 59
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(03)00697-5

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## Analogues of 3-dehydroshikimic acid which lack the C-4 and C-5 hydroxyl groups have been synthesised and assayed as substrates for shikimate dehydrogenase. The presence of the C-4 hydroxyl group is found to be very important for specificity, whereas the C-5 hydroxyl group is not. The enzyme exh