✦ LIBER ✦
Specificity of E. Coli shikimate dehydrogenase towards analogues of 3-dehydroshikimic acid
✍ Scribed by Timothy D.H. Bugg; Chris Abell; John R. Coggins
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 241 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Analogues of 3-dehydroshikimic acid which lack the C-4 and C-5 hydroxyl groups have been
synthesised and assayed as substrates for shikimate dehydrogenase. The presence of the C-4 hydroxyl group is found to be very important for specificity, whereas the C-5 hydroxyl group is not. The enzyme exhibits enandoselectivity at C-l and C4 of the racemic substrate analogues.