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Diffusion/microcirculation MRI in the rat brain

✍ Scribed by J. R. Macfall; J. H. Maki; G. A. Johnson; L. Hedlund; H. Benveniste; G. Copher

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 377 KB
Volume: 19
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910190219

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The CO~2~ fraction of an anesthetized rat's breathing mixture was changed (from 0 to 10%) to attempt to change the brain microcirculation and observe these changes in diffusion measurements of the neural tissue. Brain apparent diffusion coefficients were measured to be (0.71 ± 0.01) × 10^−1^ mm^2^/s before sacrifice and (0.39 ± 0.01) × 10^−3^ mm^2^/s after sacrifice. Multiple diffusion components were observed, consistent with flowing material, but the extra components did not increase with increased CO~2~. It is proposed that the additional components may be due to extracellular, extravascular water such as CSF. © 1991 Academic Press, Inc.

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