✦ LIBER ✦

Diffusion-weighted MRI of the lung with hyperpolarized helium-3: A study of reproducibility

✍ Scribed by Andreas E. Morbach; Klaus K. Gast; Jörg Schmiedeskamp; Anja Dahmen; Annette Herweling; Claus P. Heussel; Hans-Ulrich Kauczor; Wolfgang G. Schreiber

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 491 KB
Volume: 21
Category: Article
ISSN: 1053-1807
DOI: 10.1002/jmri.20300

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Purpose

To determine the reproducibility of several parameters of the ADC measurement by calculating the scan‐to‐scan intrasubject variability.

Materials and Methods

Measurements were performed using a gradient‐echo sequence with a bipolar gradient for diffusion weighting (b = 3.89 sec/cm^2^). Five patients with pulmonary emphysema, and six healthy‐lung volunteers were included in the study. Images were acquired after inspiration of ^3^He during a single inspiratory breath‐hold. To assess the reproducibility, the measurement was performed twice (time between measurements = 20 minutes) without repositioning the subjects. Analysis was performed on the basis of region‐of‐interest (ROI) analysis and global lung ADC histograms.

Results

The mean ADC of a ROI varied by 5.1% between two measurements for volunteers and by 6.1% for patients. In the global evaluation, the 75th percentile demonstrated the best reproducibility (2%), while other parameters showed variations up to 12%. Only the variation of the standard deviation (SD) and the measure of homogeneity of the ADC map showed a significant difference between patients and volunteers.

Conclusion

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