Abstract
Imaging with hyperpolarized 3‐helium is becoming an increasingly important technique for MRI diagnostics of the lung but is hampered by long breath holds (>20 sec), which are not always applicable in patients with severe lung disease like chronic obstructive pulmonary disease (COPD) or α‐1‐anti‐trypsin deficiency. Additionally, oxygen‐induced depolarization decay during the long breath holds complicates interpretation of functional data such as apparent diffusion coefficients. To address these issues, we describe and validate a 1.5‐T, 32‐channel array coil for accelerated ^3^He lung imaging and demonstrate its ability to speed up imaging ^3^He. A signal‐to‐noise ratio increase of up to a factor of 17 was observed compared to a conventional double‐resonant birdcage for unaccelerated imaging, potentially allowing increased image resolution or decreased gas production requirements. Accelerated imaging of the whole lung with one‐dimensional and two‐dimensional acceleration factors of 4 and 4 × 2, respectively, was achieved while still retaining excellent image quality. Finally, the potential of highly parallel detection in lung imaging is demonstrated with high‐resolution morphologic and functional images. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.