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Diffusion of Nodal Signaling Activity in the Absence of the Feedback Inhibitor Lefty2

✍ Scribed by Chikara Meno; Jun Takeuchi; Rui Sakuma; Kazuko Koshiba-Takeuchi; Sachiko Ohishi; Yukio Saijoh; Jun-ichi Miyazaki; Peter ten Dijke; Toshihiko Ogura; Hiroshi Hamada

Book ID
117795026
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
569 KB
Volume
1
Category
Article
ISSN
1534-5807

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πŸ“œ SIMILAR VOLUMES

Mouse Lefty2 and Zebrafish Antivin Are F
Mouse Lefty2 and Zebrafish Antivin Are Feedback Inhibitors of Nodal Signaling during Vertebrate Gastrulation
✍ Chikara Meno; Kira Gritsman; Sachiko Ohishi; Yasuhisa Ohfuji; Elizabeth Hecksche πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 English βš– 476 KB

Mammalian lefty and zebrafish antivin form a subgroup of the TGF beta superfamily. We report that mouse mutants for lefty2 have an expanded primitive streak and form excess mesoderm, a phenotype opposite to that of mutants for the TGF beta gene nodal. Analogously, overexpression of Antivin or Lefty2