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Differentiation of the cardiac and pulmonary toxicity of monocrotaline, a pyrrolizidine alkaloid

✍ Scribed by W. Mark Lafranconi; Raymond C. Duhamel; Klaus Brendel; Ryan J. Huxtable

Book ID
115777703
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
533 KB
Volume
33
Category
Article
ISSN
0006-2952

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## Reaction of dehydmmonocrotaline (3), the putative toxic metabolite of the carcinogenic pyrrolizidinc alkaloid monoerotahne (Z), with various nucleosides proceeded mostly at the C-9" position of 3 to give several nitrogen atom-alkylated nucleosides including N-7 alkylated 2'deoxyguanosine 14. P