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Differentiation of parenchymal lung disorders with in vitro proton nuclear magnetic resonance

✍ Scribed by Simon Vinitski; Michael G. Pearson; Stephen J. Karlik; W. Keith C. Morgan; Lewis S. Carey; Garth Perkins; Tohihiro Goto; Dean Befus

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
320 KB
Volume
3
Category
Article
ISSN
0740-3194

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✦ Synopsis

We investigated in vitro NMR properties of bleomycin-induced alveolitis and pulmonary fibrosis in 18 Lewis rats (6 controls). When alveolitis or fibrosis had developed, animal lungs were excised and examined histologically and gravimetrically and their TI and T, were determined by a NMR spectrometer at 10.7 MHz and 37Β°C. Clinical diagnosis was confirmed histologically in each case. The NMR signal intensities were significantly elevated in both disease states (P < 0.001). Both TI and T2 values of alveolitic lungs were about the same as in controls, but were significantly decreased in fibrotic lungs (P < 0.01). Changes in T, and T, correlated well (P < 0.001) with changes in water content of diseased hngs.

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