The inhibitors of cyclic AMP phosphodiesterase (papaverine and rl-(-S-butoxy-4methoxybenzyl)-2-imidazolidinone). serum-free medium, and x irradiation caused cell death and neurite formation in human neuroblastoma cells in culture (IMR-SP), whereas theophylline was ineffective. Prostaglandin (PG)E,,
Differentiation of human neuroblastoma cells in culture
β Scribed by Uriel Z. Littauer; Maria Y. Giovanni; Mary Catherine Glick
- Book ID
- 118313670
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- English
- Weight
- 378 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0006-291X
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## Abstract In addition to cell death, 6βthioguanine (TG) and 6βmercaptopurine induced neurite formation in mouse neuroblastoma cell culture, whereas 2βaminopurine had no effect on growth or morphology. 6βTG was much more potent in causing morphological differentiation than any other agents used in