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Differentiation of neuroblastoma cells induced in culture by 6-thioguanine

✍ Scribed by Kedar N. Prasad

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
433 KB
Volume
12
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

In addition to cell death, 6‐thioguanine (TG) and 6‐mercaptopurine induced neurite formation in mouse neuroblastoma cell culture, whereas 2‐aminopurine had no effect on growth or morphology. 6‐TG was much more potent in causing morphological differentiation than any other agents used in this study. It increased the levels of catechol‐o‐methyltransferase and choline acetyltransferase, but had no significant effect on the tyrosine hydroxylase (TH) activity. 5‐bromodeoxyuridine increased the levels of all three enzymes. 6‐TG produced cell death with very little neurite formation in human neuroblastoma cell culture.

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